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What is Linalool?

Understanding Linalool: A Closer Look at the Aromatic Terpene

One of the fascinating compounds found in cannabis flowers is linalool. As one of over 200 terpenes synthesised in cannabis, linalool comprises approximately 6% of the plant’s essential oil. Let’s delve deeper into the aroma, possible effects, and supporting research surrounding this unique compound.

Aroma

Known for its zesty, slightly stinging scent reminiscent of citrus fruits, linalool brings a fresh and pleasant aroma that is hard to miss. This terpene underpins the recognisable scent of cannabis while also contributing to the aromatic essence found in wood, flowers, citrus, and lavender. Linalool is not exclusive to cannabis; it can be found in many other plant species such as lavender, rose, basil, cilantro, and more, offering its pleasant scent to various herbs and fruits.

Possible Effects

Research on linalool’s therapeutic effects continues to progress, with studies hinting at several potential benefits. Some of the possible effects associated with linalool include anxiolytic, antidepressive, sedative, analgesic, and anticonvulsant properties. Additionally, linalool has shown to enhance the therapeutic effects of various cannabinoids, highlighting its role in the entourage effect.

Supporting Research

When it comes to the supporting research on linalool, there is evidence to suggest that this terpene can exert anxiolytic, antidepressant, sedative, analgesic, and anticonvulsant effects. For instance, studies have shown that linalool could help reduce anxiety by decreasing serotonin receptor activity and enhancing parasympathetic nervous system activity. Furthermore, linalool has demonstrated potential antidepressant-like activity through the monoaminergic system and sedative effects in animal models.

Overall, linalool appears to hold promise as a therapeutic compound, with further research needed to fully uncover its potential benefits. As scientists continue to unravel the complexities of cannabis and its components, linalool stands out as a compound worth exploring further for its unique properties.

Sources

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[3] Russo, E. B. (2011c). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. NCBI. Published. [Source]

[4] Malcolm, B. J., & Tallian, K. (2017). Essential oil of lavender in anxiety disorders: Ready for prime time? NCBI. [Source]

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[6] Harada, H., Kashiwadani, H., Kanmura, Y., & Kuwaki, T. (2018). Linalool Odor-Induced Anxiolytic Effects in Mice. Frontiers in Behavioral Neuroscience, 12. [Source]

[7] Linck, V., da Silva, A., Figueir, M., Caram, E., Moreno, P., & Elisabetsky, E. (2010). Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice. Phytomedicine, 17(8-9), 679-683. [Source]

[8] Guzm, S. L., Bonilla-Jaime, H., Gmez-Cansino, R., & Reyes-Chilpa, R. (2015). Linalool and –pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sciences, 128, 24-29. [Source]

[9] Coelho, V., Mazzardo-Martins, L., Martins, D. F., Santos, A. R. S., da Silva Brum, L. F., Picada, J. N., & Pereira, P. (2013). Neurobehavioral and genotoxic evaluation of (-)-linalool in mice. Journal of Natural Medicines, 67(4), 876-880. [Source]

[10] Linck, V. D. M., da Silva, A. L., Figueir, M., Luis Piato, N., Paula Herrmann, A., Dupont Birck, F., Bastos Caram, E., Svio Nunes, D., Moreno, P. R. H., & Elisabetsky, E. (2009). Inhaled linalool-induced sedation in mice. Phytomedicine, 16(4), 303-307. [Source]

[11] Peana, A. T., D’Aquila, P. S., Chessa, M., Moretti, M. D., Serra, G., & Pippia, P. (2003). (-)-Linalool produces antinociception in two experimental models of pain. European Journal of Pharmacology, 460(1), 37-41. [Source]

[12] Russo, E. B., & Marcu, J. (2017c). Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Cannabinoid Pharmacology, 67-134. [Source]